Patel, Gautam; Roncal, Norma E.; Lee, Patricia J.; Leed, Susan E.; Erath, Jessey; Rodriguez, Ana; Sciotti, Richard J.; Pollastri, Michael P. published an article in 2014, the title of the article was Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.Quality Control of (Trimethoxymethyl)benzene And the article contains the following content:
Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity relationships for each parasite. In this study, we identified multiple non-toxic compounds with high potency against T. brucei and P. falciparum with good selectivity. These compounds may represent an opportunity for continued optimization. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Quality Control of (Trimethoxymethyl)benzene
The Article related to aurora kinase inhibitor hesperadin analog trypanosoma antiprotozoal drug discovery, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Quality Control of (Trimethoxymethyl)benzene
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