Moroder, Luis; Borin, Gianfranco; Filippi, Bruno; Stivanello, Diego; Marchiori, Fernando published an article in 1977, the title of the article was Studies on cytochrome c. XII. Synthesis of the protected undecapeptide (sequence 66-76) and pentadecapeptide (sequence 66-80) of horse heart cytochrome c.COA of Formula: C10H19NO4 And the article contains the following content:
Z-Glu-Tyr-Leu-Glu-Asn-Pro-Lys(TFA)-Lys(TFA)-Tyr-Ile-Pro-NHNH2 (I; Z = PhCH2O2C, TFA = CF3CO), the protected 66-76 fragment of horse heart cytochrome c was prepared by coupling Z-Glu(OCMe3)-Tyr-Leu-Glu(OCMe3)-NHNH2 (II) to H-Asn-Pro-Lys(TFA)-Lys(TFA)-Tyr(CMe3)-Ile-Pro-NHNHCO2CMe3 by the azide method and partially deblocking the resulting undecapeptide with CF3CO2H. I was coupled to H-Gly-Thr(CMe3)-Lys(TFA)-Met-NHNHCO2Me3 (III) by the azide method to give the corresponding protected pentadecapeptide which was the protected 66-80 fragment of cytochrome c. II and III were prepared by conventional stepwise peptide couplings. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4
The Article related to cytochrome c undecapeptide pentadecapeptide synthesis, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.COA of Formula: C10H19NO4
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