On September 1, 2019, Gaalova, Jana; Hejda, Stanislav; Stavarek, Petr; Sykora, Jan; Fajgar, Radek; Kluson, Petr; Izak, Pavel published an article.Quality Control of (R)-Methyl 3-hydroxybutanoate The title of the article was Pervaporation of (R)/(S)-methyl 3-hydroxybutyrate (∑MHB) from a mixture containing an ionic liquid, methanol and Ru catalyst. And the article contained the following:
Complex technologies in the production of fine chems. bring together various connected processes, each bringing specific green chem. challenges. A valuable mixture arises in the stereoselective hydrogenation of methyl-acetoacetate (MAA) to (R)- and (S)- Me 3-hydroxybutyrate (∑MHB) over Ru organometallic complex (R)-Ru/BINAP, and in a “green” tetra-alkylammonium bistriflimide/methanol/water solvent phase. The reaction could be carried out in various arrangements, e.g. in a batch mode, in a continuous stirred-tank reactor, or even in a tubular microfluidic chip reactor. In either case, the valuable optically pure Ru complex has been sought to be effectively separated, and potentially recycled. The ionic liquid phase (tetra-alkylammonium bistriflimide) is intended for selective accommodation of the complex in the reaction mixture and as a green alternative to other solvents. It was the main issue of this work to design a specific separation unit, to construct it, and to optimize its performance towards the efficient separation of ∑MHB from the ionic liquid phase bearing the (R)-Ru/BINAP complex. The unit was developed to be connected with the complex preparation process, employing the microreactor fluid flow platform. The separation part of the overall technol. was designed as a membrane pervaporation. The membrane separation proceeded with different feed mixtures combining ∑methyl 3-hydroxybutyrate, methanol, ionic liquid and/or the catalyst. The technique was applied at various temperatures, using the industrial composite PDMS membrane, PERVAP 4060 from Sulzer. The feed as well as the pervaporate were analyzed by NMR spectroscopy and IR spectroscopy. The enrichment factor of the ∑MHB with respect to the retentate was 1.24 and the ∑MHB permeate mass flux was 61 g h-1 m-2. In addition, the membrane was characterized by SEM and energy dispersive X-ray microanal. after the membrane process, showing no sorption of the catalyst into the membrane. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Quality Control of (R)-Methyl 3-hydroxybutanoate
The Article related to pdms membrane methyl hydroxybutyrate pervaporation ionic liquid ru catalyst, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Quality Control of (R)-Methyl 3-hydroxybutanoate
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