On March 21, 2019, Brownstein, Michael J. published a patent.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of azetidinone derivatives for use in treating brain injury. And the patent contained the following:
Title compounds I [A = CO2H, ester, or amide; B = OH, SH, CO2H, ester, or amide; R1 = H or alkyl; R2 = H, halo, CN, alkyl, alkoxy, etc.; R3 = amino, amido, acylamido, (un)substituted ureido, etc.; R4 = alkyl, (un)substituted aryl, arylalkyl, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed for use in treating brain injurys. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in V1a binding assays, e.g., II demonstrated an IC50 value of 0.49 nM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
The Article related to azetidinone preparation brain injury, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate
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