On April 27, 2021, Yang, Xiaobao; Jiang, Biao; Tan, Wenfu; Xu, Zhongli; Luo, Jia; Wang, Juan; Yang, Jun; Zhang, Shaoqing published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of (aminonitrophenyl)sulfonylpiperazinylbenzamides as protein degradation agents. And the patent contained the following:
The present invention relates to the preparation of (aminonitrophenyl)sulfonylpiperazinylbenzamides, R1-A1-LIN-A2-R2, as protein degradation agents. In particular, R1-A1-LIN-A2-R2, wherein, R1 is 4-[[4-[[4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-cyclohexen-1-yl]methyl]piperazin-1-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl]-2-nitro-anilino]methyl]-1-piperidyl, 3-[[4-[[4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-cyclohexen-1-yl]methyl]piperazin-1-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzoyl]sulfamoyl]-2-nitro-anilino]methyl]-1-piperidyl, 3-(4-chlorophenyl)-2-[[4-[4-[[3-nitro-4-(tetrahydropyran-4-ylmethylamino)phenyl]sulfonylcarbamoyl]-3-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)phenyl]piperazin-1-yl]methyl]phenoxy, etc.; A1 does not exist or represents a carbonyl group; A2 does not exist or represents a carbonyl group. Further LIN does not exist or represents a (un)substituted linear or branched alkylene group, wherein the alkylene group is optionally selected from oxygen, the group consisting of an optionally substituted heterocyclyl or any combination thereof is interrupted, when LIN does not exist, one of A1 and A2 does not exist and the other represents a carbonyl group, and R2 is I and II, wherein the R3 group represents an ethylene group or a vinylene group or salt, enantiomer, stereoisomer, solvate, polymorph thereof, and application thereof for treating diseases, were prepared The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Category: esters-buliding-blocks
The Article related to aminonitrophenyl sulfonylpiperazinylbenzamide protein degradation agent preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.Category: esters-buliding-blocks
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