On October 17, 2019, Yang, Xiaobao; Jiang, Biao; Sun, Renhong; Ren, Chaowei; Sun, Ning; Kong, Ying; Li, Yan; Chen, Jinju; Yin, Qianqian; Song, Xiaoling; Zhao, Quanju; Qiu, Xing published a patent.Formula: C17H26O7S The title of the patent was Protein degradation targeting compound, anti-tumor application, intermediate thereof and use of intermediate. And the patent contained the following:
The compound (e.g., I) has a degrading effect on a specific target protein, and is mainly composed of three parts: the first part is Small Mols. Binding Protein (SMBP); the second part is a linker unit (LIN); and the third part is a Ubiquitin Ligase Binding Moiety (ULM), wherein SMBP and LIN are covalently bound, and LIN is covalently bound to ULM. The compounds designed and synthesized by the present disclosure have a wide pharmacol. activities, have a function of degrading specific proteins and/or inhibiting activities, and can be used for the treatment of associated tumor. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Formula: C17H26O7S
The Article related to protein degradation targeting heteroaryl preparation antitumor smbp lin ulm, small mol binding protein smbp linker lin ulm, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Formula: C17H26O7S
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