Widmer, Fred; Breddam, Klaus; Johansen, Jack T. published an article in 1980, the title of the article was Carboxypeptidase Y catalyzed peptide synthesis using amino acid alkyl esters as amine components.HPLC of Formula: 53838-27-0 And the article contains the following content:
Carboxypeptidase catalyzed peptide coupling reactions of Bz-Ala-OMe with amino acid alkyl esters and the peptide coupling of N-protected dipeptide Me esters with amino acid alkyl esters. The yield of peptide and the extent of oligomerization of the amine components depended on the nature of the amino acid side chains and the nature of the alkyl ester. The Me esters of hydrophobic amino acids oligomerized to various extents with total product yields of 60-90%, whereas the Me esters of hydrophilic amino acids did not oligomerize and gave peptides in 25-50% yields. As the size of the alkyl ester was increased, the degree of oligomerization was drastically decreased. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).HPLC of Formula: 53838-27-0
The Article related to carboxypeptidase catalyst peptide coupling, alkyl ester amino acid peptide carboxypeptidase, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.HPLC of Formula: 53838-27-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics