On October 4, 2022, Wannenmacher, Nick; Heberle, Martin; Yu, Xin; Demircan, Ayseguel; Wanner, Daniel M.; Pfeffer, Camilla; Peters, Rene published an article.Related Products of 517-23-7 The title of the article was Diastereospecific Enantiodivergent Allylation of Pyrazolones as an Entry to β-Aminoamides. And the article contained the following:
A diastereospecific enantiodivergent allylation of pyrazolones I (R1 = n-Pr, H2C:CHCH2, PhCH2, etc.; R2 = Me, i-Pr, Ph; R3 = Ph, PhCH2, 4-MeOC6H4) with allyl imidates R4CH:CHCH2OC(:NH)CCl3 (R4 = Me, n-Pr, PhCH2CH2, MeO2CCH2CH2, PhCH2OCH2CH2), catalyzed by a planar chiral pentaphenylferrocene-based palladacycle, is reported. With the same catalyst, both enantiomeric products II were selectively available from (E)- or (Z)-allyl imidates. The method is applicable to structurally diverse substrates and gave products II with 85-94% enantiomeric excesses. In addition, pyrazolone (S,E)-II (R1 = 4-FC6H4CH2; R2 = Me; R3 = Ph; R4 = PhCH2CH2) was transformed into acyclic β-aminoamide. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Related Products of 517-23-7
The Article related to amide amino asym synthesis, allyl pyrazolone asym synthesis oxidative ring opening, pyrazolone enantiodivergent allylation allyl imidate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 517-23-7
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