On September 15, 2012, Reis, Joel S.; Andrade, Leandro H. published an article.Name: (R)-Methyl 3-hydroxybutanoate The title of the article was Lipase-catalyzed kinetic resolution of β-borylated carboxylic esters. And the article contained the following:
The kinetic resolution of chiral β-borylated carboxylic esters via lipase-catalyzed hydrolysis and transesterification reactions was studied. The enantioselective hydrolysis catalyzed by CAL-B furnished the β-borylated carboxylic acid with reasonable enantiomeric excess (62% ee), while both Me and Et β-borylated carboxylic esters were recovered with excellent ee (>99%). Meanwhile, the transesterification reaction of β-borylated carboxylic esters and several alcs., catalyzed by CAL-B, only indicated a high selectivity when ethanol and methyl-(β-pinacolylboronate)-butanoate were used as substrates, which gave ethyl-(β-pinacolylboronate)-butanoate with >99% ee. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Name: (R)-Methyl 3-hydroxybutanoate
The Article related to kinetic resolution lipase catalyzed beta borylated carboxylic esters preparation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Name: (R)-Methyl 3-hydroxybutanoate
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