On April 8, 1981, Meienhofer, Johannes Arnold published a patent.COA of Formula: C10H19NO4 The title of the patent was Peptides and their pharmaceutical preparations. And the patent contained the following:
Peptides H-X-Glu-Asn-OH (I; X = null, Ala, Glu-Ala, Glu-Glu-Ala, Val-Glu-Glu-Ala, Val-Val-Glu-Glu-Ala) were prepared as agents for influencing the regulation, differentiation, and function of thymus lymphocytes. Thus, Z-Ala-OH (Z = PhCH2O2C) was coupled to H-Glu(OCMe3)-Asn-OCMe3 by ClCO2CH2CHMe2 to give 81.7% Z-Ala-Glu(OCMe3)-Asn-OCMe3, which was Z-deblocked by hydrogenolysis over Pd/BaSO4 to give 96.8% H-Ala-Glu(OCMe3)-Asn-OCMe3, which was deblocked by CF3CO2H to give 60.4% H-Ala-Glu-Asn-OH. The effects of I on glucocorticoid resistance of mouse thymus cells were determined and these activities were compared to those of thymosin α1 and thymosin fraction 5. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4
The Article related to glutamylasparagine peptide preparation lymphocyte t differentiation, thymus cell glutamylasparagine peptide influence, Synthesis of Amino Acids, Peptides, and Proteins: Peptides and other aspects.COA of Formula: C10H19NO4
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