On September 28, 2006, Koppel, Gary A. published a patent.COA of Formula: C10H19NO4 The title of the patent was Preparation of β-lactams as vasopressin V1b antagonists.. And the patent contained the following:
Title compounds [I; A = carboxylic acid, ester, amide; B = A, alc, thiol, derivative thereof; R1 = H, alkyl; R2 = H, alkyl, alkoxy, alkylthio, cyano, CHO, alkylcarbonyl, etc.; R3 = (substituted) amino, amido, acylamido, ureido, N-containing heterocyclyl; R4 = alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl, (substituted) aryl, aralkyl, arylhaloalkyl, aralkoxyalkyl, aralkenyl, aralkynyl, etc.], were prepared Thus, title compound [II; A = (R)-1,2,3,4-tetrahydronaphth-1-ylamino] [preparation using L-glutamic acid γ-tert-Bu ester-α-4-cyclohexylpiperazinylamide, cinnamaldehyde, and (S)-2-(4-phenyloxazolidin-2-on-3-yl)acetyl chloride outlined] showed rat V1b binding affinity with IC50 = 0.05 μM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).COA of Formula: C10H19NO4
The Article related to beta lactam preparation vasopressin v1b antagonist, anxiety depression obsessive compulsive disorder impulsivity treatment azetidinone, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.COA of Formula: C10H19NO4
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