On December 18, 2018, Wilkins, Laura E.; Badi, Nezha; Du Prez, Filip; Gibson, Matthew I. published an article.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride The title of the article was Double-Modified Glycopolymers from Thiolactones to Modulate Lectin Selectivity and Affinity. And the article contained the following:
Multivalent glycomaterials show high affinity toward lectins but are often nonselective as they lack the precise 3-D presentation found in native glycans. Here, thiolactone chem. is exploited to enable the synthesis of glycopolymers with both a primary binding (galactose) and a variable secondary binding unit in close proximity to each other on the linker. These polymers are used to target the Cholera toxin B subunit, CTxB, inspired by its native branched glycan target, GM-1. The secondary, nonbinding unit was shown to dramatically modulate affinity and selectivity toward the Cholera toxin. These increasingly complex glycopolymers, assembled using accessible chem., can help breach the synthetic/biol. divide to obtain future glycomimetics. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
The Article related to modified glycopolymer thiolactone lectin selectivity affinity, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride
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