On August 10, 2022, Yang, Guoqiang; Wu, Hua; Gallarati, Simone; Corminboeuf, Clemence; Wang, Qian; Zhu, Jieping published an article.COA of Formula: C9H8F2O2 The title of the article was Migrative Carbofluorination of Saturated Amides Enabled by Pd-Based Dyotropic Rearrangement. And the article contained the following:
Herein, a palladium-catalyzed migrative carbofluorination of saturated amides enabled by the activation of both the C(sp3)-H and the Cquaternary-Cσ bonds was reported for the synthesis of functionalized amides. In this transformation, the α-quaternary carbon of Weinreb amides was converted to α-tertiary fluoride with concurrent migration of an aryl or an amido group from the α- to β-carbon. DFT calculations indicate that the dyotropic rearrangement proceeds through an unusual anti-selective [2.1.0] bicyclic transition state. The experimental process involved the reaction of Methyl 2-(2,6-difluorophenyl)acetate(cas: 872046-08-7).COA of Formula: C9H8F2O2
The Article related to functionalized amide preparation, saturated amide dyotropic rearrangement migrative carbofluorination palladium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H8F2O2
Referemce:
Ester – Wikipedia,
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