Wauke, Hisashi; Matsuo, Kazumasa; Matsumoto, Kenji; Shindo, Mitsuru published an article in 2016, the title of the article was Synthesis of Dissymmetric Malonic Acid Monoamides from Symmetric Dithiomalonates.Computed Properties of 85-91-6 And the article contains the following content:
A highly selective synthesis of dissym. S,N-malonates from sym. dithiomalonates under mild conditions has been reported. This reaction was accelerated using a previously developed Cu(II) catalyst. When an aliphatic amine, such as dibenzylamine, diallylamine, diisopropylamine, etc. was used as the nucleophile, the amine also worked as a base and accelerated the amination reaction. Kinetic studies indicated that the key step of this reaction is the thermal formation of an acylketene, and its stability mainly contributes to the selectivity of the reaction. The synthetic utility of dissym. S,N-malonates is also shown by the synthesis of linomide. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Computed Properties of 85-91-6
The Article related to malonic acid monoamide preparation, dithiomalonate amine amidation copper catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Computed Properties of 85-91-6
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