On July 31, 2021, Wang, Yakun; Wang, Shuaifei; Zhang, Conghui; Zhao, Ting; Hu, Yanqin; Zhang, Mingwei; Chen, Pengli; Fu, Yang published an article.Computed Properties of 10472-24-9 The title of the article was Highly Selective Difluoromethylations of β-Keto Amides with TMSCF2Br under Mild Conditions. And the article contained the following:
Without employing any transition metal and other additives, efficient methods for selective difluoromethylations of β-keto amides with TMSCF2Br reagent were developed under mild conditions. This protocol allowed a convenient access to various α-difluoromethyl β-keto amides with excellent yields (up to 93%) and high carbon/oxygen (C/O) regioselectivities (up to 99:1). The C/O selectivity of β-keto amides was easily reversed and controlled by simply changing the base. This protocol was easily scaled-up and the C-difluoromethylation product was reduced into CF2H-containing amino alc. derivatives Moreover, the first enantioselective electrophilic difluoromethylation of β-keto amides was achieved by phase-transfer catalysis. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Computed Properties of 10472-24-9
The Article related to keto amide bromodifluoromethyl trimethylsilane regioselective chemoselective difluoromethylation, difluoromethyl keto amide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Computed Properties of 10472-24-9
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