On November 6, 2020, Li, Gonglin; Liu, Mohuizi; Zou, Sijia; Feng, Xiaoming; Lin, Lili published an article.Formula: C19H26N2O3 The title of the article was A Bispidine-Based Chiral Amine Catalyst for Asymmetric Mannich Reaction of Ketones with Isatin Ketimines. And the article contained the following:
A unique chiral amine organocatalyst with a bispidine structure was found to be efficient for the diastereo- and enantioselective Mannich reaction of isatin ketimines with ketones. A series of 3-substituted 3-amino-2-oxindoles, e.g., I, bearing vicinal tertiary and quaternary chiral stereogenic centers were obtained in excellent yields with excellent dr and ee values. The gram-scale synthesis and transformation of the product showed the practicability of this methodol. In addition, a possible transition state model was proposed to explain the origin of the stereoselectivity. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Formula: C19H26N2O3
The Article related to isatin ketimine ketone enantioselective diastereoselective bispidine chiral catalyst mannich, amino oxindole stereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C19H26N2O3
Referemce:
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