On June 30, 2019, Lee, Hye Lim; Kim, Song-Yi; Kim, Eun Ji; Han, Da Ye; Kim, Bong-Gyu; Ahn, Joong-Hoon published an article.HPLC of Formula: 85-91-6 The title of the article was Synthesis of methylated anthranilate derivatives using engineered strains of Escherichia coli. And the article contained the following:
Anthranilate derivatives have been used as flavoring and fragrant agents for a long time. Recently, these compounds are gaining attention due to new biol. functions including antinociceptive and analgesic activities. Three anthranilate derivatives, N-methylanthranilate, Me anthranilate, and Me N-methylanthranilate were synthesized using metabolically engineered stains of Escherichia coli. NMT encoding N-methyltransferase from Ruta graveolens, AMAT encoding anthraniloyl-CoA (CoA):methanol acyltransferase from Vitis labrusca, and pqsA encoding anthranilate CoA ligase from Pseudomonas aeruginosa were cloned and E. coli strains harboring these genes were used to synthesize the three desired compounds E. coli mutants (metJ, trpD, tyrR mutants), which provide more anthranilate and/or S-adenosyl methionine, were used to increase the production of the synthesized compounds MS/MS anal. was used to determine the structure of the products. Approx., 185.3μM N-methylanthranilate and 95.2μM Me N-methylanthranilate were synthesized. This is the first report about the synthesis of anthranilate derivatives in E. coli. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).HPLC of Formula: 85-91-6
The Article related to escherichia methylated anthranilate derivative engineering, anthranilate, n-methyltransferase, anthraniloyl-coenzyme a (coa):methanol acyltransferase, metabolic engineering and other aspects.HPLC of Formula: 85-91-6
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