Frutos-Pedreno, Roberto; Garcia-Lopez, Jose-Antonio published an article in 2016, the title of the article was 2-Arylacetamides as Versatile Precursors for 3-Aminoisocoumarin and Homophthalimide Derivatives: Palladium-Catalyzed Cascade Double Carbonylation Reactions.Synthetic Route of 85-91-6 And the article contains the following content:
The synthesis of biol. relevant homophthalimide and 3-aminoisocoumarin nuclei via palladium-catalyzed carbonylation of 2-(2-iodoaryl)acetamides was developed. The degree of N-substitution on the starting amide substrate dictates whether C-N or C-O coupling takes place in the final step of the catalytic cycle giving rise to each type of heterocycle. The introduction of a second C-halogen bond in the starting acetamides allows a catalytic cascade double carbonylation involving a C-H activation step to give fused heterocyclic structures. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Synthetic Route of 85-91-6
The Article related to homophthalimide aminoisocoumarin preparation palladium catalyst iodoarylacetamide carbonylation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Synthetic Route of 85-91-6
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