On March 26, 2020, Follows, Bruce; Kayser-Bricker, Katherine J.; Talbot, Adam Charles; Mente, Scot; Shelekhin, Tatiana; Ericsson, Anna published a patent.Product Details of 227940-70-7 The title of the patent was Preparation of pyrrolo-pyrrolyl alkanones as ubiquitin specific peptidase 9X inhibitors useful for treatment of cancer. And the patent contained the following:
The disclosure provides novel chem. compounds of formula I useful as inhibitors of ubiquitin specific peptidase 9X (USP9X) useful for treatment of diseases and disorders associated with modulation of USP9X such as cancer. Compounds of formula I [wherein X = CR5R6, CR5, NR5, or N; dashed bonds are independently single or double bonds; Y1, Y2, and Y3 independently = N or CRa; Ra independently = H, halo, or CN; Ring A = (un)substituted 5- to 6-membered aryl, (un)substituted 5- to 6-membered heteroaryl, (un)substituted 5- to 7-membered heterocyclyl, etc.; Z1 = O, S, or NR; Z2 = O or NR; W = CH2 and derivative, O, S, etc.; m = 0 or 1; R1 and R2 independently = H, halo, C1-6alkyl, etc.; R3, R4, R5, R6, R7, R8, R9, and R10 independently = H, (un)substituted C1-6alkyl, (un)substituted C3-8cycloalkyl, etc.; each R independently = H, OH, NH2, O(C1-6alkyl), etc.; B = monocyclic or bicyclic 3- to 14-membered ring] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compounds (R)-II and (S)-II were prepared from a multistep preparation culminating in chiral separation (preparation given). Exemplified I were evaluated for USP9X inhibitory activity from which both (R)- and (S)-II isomers demonstrated IC50 between ≤ 0.2μM and ≥ 0.05μM. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Product Details of 227940-70-7
The Article related to pyrrolopyrrolyl alkanone preparation ubiquitin specific peptidase9x inhibitor cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Product Details of 227940-70-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics