Bayer, Andreas; Wijaya, Bernard; Rademacher, Franziska; Moebus, Lena; Preuss, Mark; Singh, Michael; Tohidnezhad, Mersedeh; Kubo, Yusuke; Rodewald, Meno; Behrendt, Peter; Weitkamp, Jan-Tobias; Glaeser, Regine; Harder, Juergen published an article in 2021, the title of the article was Platelet-Released Growth Factors Induce Genes Involved in Extracellular Matrix Formation in Human Fibroblasts.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:
Platelet concentrate products are increasingly used in many medical disciplines due to their regenerative properties. As they contain a variety of chemokines, cytokines, and growth factors, they are used to support the healing of chronic or complicated wounds. To date, underlying cellular mechanisms have been insufficiently investigated. Therefore, we analyzed the influence of Platelet-Released Growth Factors (PRGF) on human dermal fibroblasts. Whole transcriptome sequencing and gene ontol. (GO) enrichment anal. of PRGF-treated fibroblasts revealed an induction of several genes involved in the formation of the extracellular matrix (ECM). Real-time PCR analyses of PRGF-treated fibroblasts and skin explants confirmed the induction of ECM-related genes, in particular transforming growth factor beta-induced protein (TGFBI), fibronectin 1 (FN1), matrix metalloproteinase-9 (MMP-9), transglutaminase 2 (TGM2), fermitin family member 1 (FERMT1), collagen type I alpha 1 (COL1A1), a disintegrin and metalloproteinase 19 (ADAM19), serpin family E member 1 (SERPINE1) and lysyl oxidase-like 3 (LOXL3). The induction of these genes was time-dependent and in part influenced by the epidermal growth factor receptor (EGFR). Moreover, PRGF induced migration and proliferation of the fibroblasts. Taken together, the observed effects of PRGF on human fibroblasts may contribute to the underlying mechanisms that support the beneficial wound-healing effects of thrombocyte concentrate products. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
The Article related to transcriptome prgf fibroblast extracellular matrix formation wound healing, extracellular matrix (ecm), fibroblasts, platelet-released growth factors (prgf), wound healing and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
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