Basavaraj, M.; Giles, D.; Das, A. K.; Sakharam, A. G. published an article in 2018, the title of the article was Synthesis and characterization of some novel indolizine derivatives.Quality Control of Ethyl indolizine-1-carboxylate And the article contains the following content:
A novel approach was adopted for the synthesis of Indolizine nucleus. Pyridinium-N-methylides were synthesized by reacting pyridine with different haloacetic acids. Further, the indolizine nucleus were synthesized through 1,3-cycloaddition of pyridinium-N-methylides with electron deficient alkynes or alkenes in presence of MnO2 to give indolizine carboxylates. Later on, derivatives of indolizine were prepared by treating indolizine carboxylates with hydralazine and metformin. Synthesis of indolizine 2-carboxylic acid was achieved, by reacting 2-Me pyridine with Et bromopyruvate. The resulting acid was treated with hydralazine and metformin to form corresponding indolizine derivatives Synthesized compounds were characterized by IR and NMR spectroscopic techniques. The experimental process involved the reaction of Ethyl indolizine-1-carboxylate(cas: 93476-46-1).Quality Control of Ethyl indolizine-1-carboxylate
The Article related to indolizinyl carbohydrazide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Ethyl indolizine-1-carboxylate
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