On October 1, 2020, Abraham, Michael H.; Abraham, Raymond J.; Aghamohammadi, Amin; Afarinkia, Kamyar; Liu, Xiangli published an article.SDS of cas: 85-91-6 The title of the article was The assessment of intramolecular hydrogen bonding in ortho-substituted anilines by an NMR method. And the article contained the following:
We describe the Δlog P method for the assessment of intramol. hydrogen bonds (IMHBs), and show that it is not a very general method of distinguishing between mols. in which there is an IMHB and mols. in which there is no IMHB. The ‘double’ Δlog P method of Shalaeva et al. is a much more reliable method for the assessment of IMHB but requires the synthesis of a model compound and the determination of no less than four water-solvent partition coefficients In addition, it is difficult to apply to compounds that contain more than one hydrogen bond acidic group capable of IMHB. We then describe our NMR method of assessing IMHB, based on 1H NMR chem. shifts in solvents DMSO and CDCl3. We have determined 1H NMR chem. shifts for a number of ortho-substituted anilines and show that the only compound we have studied that forms an IMHB is Me 2-methylaminobenzoate though there is no IMHB present in Me 2-aminobenzoate. This apparently anomalous result is supported by both MM and ab initio calculations The NMR method is much simpler and less time consuming than other methods for the assessment of IMHB. It provides a quant. assessment of IMHB and can be applied to mols. with more than one hydrogen bond acidic group. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).SDS of cas: 85-91-6
The Article related to ortho aniline nmr chem shift hydrogen bond, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.SDS of cas: 85-91-6
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