On June 24, 2020, Yang, Yonghong; Fryer, Claudia; Sharkey, Jack; Thomas, Aidan; Wais, Ulrike; Jackson, Alexander W.; Wilm, Bettina; Murray, Patricia; Zhang, Haifei published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Perylene Diimide Nanoprobes for In Vivo Tracking of Mesenchymal Stromal Cells Using Photoacoustic Imaging. And the article contained the following:
Noninvasive bioimaging techniques are critical for assessing the biodistribution of cellular therapies longitudinally. Among them, photoacoustic imaging (PAI) can generate high-resolution images with a tissue penetration depth of ~4 cm. However, it is essential and still highly challenging to develop stable and efficient near-IR (NIR) probes with low toxicity for PAI. The authors report here the preparation and use of perylene diimide derivative (PDI) with NIR absorbance (around 700 nm) as nanoprobes for tracking mesenchymal stromal cells (MSCs) in mice. Employing an inhouse synthesized star hyperbranched polymer as a stabilizer is the key to the formation of stable PDI nanoparticles with low toxicity and high uptake by the MSCs. The PDI nanoparticles remain within the MSCs as demonstrated by in vitro and in vivo assessments. The PDI-labeled MSCs injected s.c. on the flanks of the mice are clearly visualized with PAI up to 11 days postadministration. Furthermore, bioluminescence imaging of PDI-labeled luciferase-expressing MSCs confirms that the administered cells remain viable for the duration of the experiment These PDI nanoprobes thus have good potential for tracking administered cells in vivo using PAI. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
The Article related to perylene diimide nanoprobe mesenchyme stromal cell photoacoustic imaging, in vivo tracking, organic nanoparticles, perylene diimide, photoacoustic imaging, star hyperbranched polymer and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)
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