Yang, Dan; Wang, Ping; Wu, Hanfu; Li, Jilan published an article in 2017, the title of the article was Synthesis and antimicrobial activities of novel quinazoline-2,4-dione acetyl hydrazones.Recommanded Product: Methyl N-Methylanthranilate And the article contains the following content:
Me 2-aminobenzoate was reacted with iodomethane to get Me N-methylanthranilate. The key intermediate 2-(6-chloro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl) acetohydrazide (I) was synthesized from Me N-methylanthranilate via substitution, hydrolysis, cyclization and hydrazinolysis reactions. Then the key intermediate I was reacted with various substituted aromatic aldehydes or ketones to afford a series of quinazolin-2,4-dione acetyl hydrazone compounds II [R1 = H, R2 = OMe-2, Cl-2, Br-2, OH-2, F-2, NO2-2, F-4, Cl-4, Br-4, OH-4, NO2-4, SMe-4, OMe-3-OH-4, NO2-3, OH-2-Cl-5 OMe-4; R1 = Me, R2 = Me-4, H, OMe-4; R1 = Et, R2 = H;]. The structures of all target compounds were characterized by means of 1H NMR, 13C NMR and MS. The preliminary bioassay indicated that the as-synthesized compounds had certain antibacterial activities against the tested strains. At the same time, some of them showed better antibacterial activities than the com. drugs such as streptomycin sulfate and polyoxin B. The experimental process involved the reaction of Methyl N-Methylanthranilate(cas: 85-91-6).Recommanded Product: Methyl N-Methylanthranilate
The Article related to quinazolinedione acetyl hydrazones preparation antimicrobial antibacterial antifungal activity, dioxodihydroquinazolinyl acetohydrazide preparation condensation aromatic aldehydes ketones and other aspects.Recommanded Product: Methyl N-Methylanthranilate
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