Xu, Ruixue; Zhan, Miao; Peng, Lingling; Pang, Xuehai; Yang, Jun; Zhang, Tao; Jiang, Hongxia; Zhao, Lifeng; Chen, Yuanwei published an article in 2015, the title of the article was Design, synthesis and biological evaluation of deuterated nintedanib for improving pharmacokinetic properties.Safety of (Trimethoxymethyl)benzene And the article contains the following content:
Nintedanib is a novel triple angiokinase inhibitor that inhibits three growth factors simultaneously. Deuterated derivatives of nintedanib I (R1 = CH3, CD3; R2 = CH3, CD3) at certain metabolically active sites were prepared and evaluated in vitro and in vivo. In particular, deuterated compound I (R1 = CH3; R2 = CD3) had significantly improved pharmacokinetic properties compared with nintedanib. These efforts lay the foundation for further investigating the druggability of I (R1 = CH3; R2 = CD3). The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Safety of (Trimethoxymethyl)benzene
The Article related to deuterated nintedanib preparation human antitumor angiokinase inhibitor pharmacokinetic property, nintedanib, antitumor activity, deuterium isotope effect, triple angiokinase inhibitor and other aspects.Safety of (Trimethoxymethyl)benzene
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