On October 16, 2015, Wang, Lizhen; Feng, Shaojie; An, Lian; Gu, Guofeng; Guo, Zhongwu published an article.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates. And the article contained the following:
Lipoarabinomannan (LAM) is one of the major constituents of the Mycobacterium tuberculosis cell wall and an attractive mol. scaffold for antituberculosis drug and vaccine development. In this paper, a convergent strategy was developed for the synthesis of LAM oligosaccharides with an α-1,2-linked dimannopyranose cap at the nonreducing end. The strategy was highlighted by efficient coupling of sep. prepared non-reducing end and reducing end oligosaccharides. Glycosylation were mainly achieved with thioglycoside donors, which gave excellent yields and stereoselectivity even for reactions between complex oligosaccharides. The strategy was utilized to successfully synthesize tetra-, hepta-, and undecasaccharides of LAM from D-arabinose in 10, 15, and 14 longest linear steps and 7.84, 7.50, and 2.59% overall yields, resp. The resultant oligosaccharides with a free amino group at their reducing end were effectively conjugated with carrier proteins, including bovine serum albumin and keyhole limpet hemocyanin (KLH), via a bifunctional linker. Preliminary immunol. studies on the KLH conjugates revealed that they could elicit robust antibody responses in mice and that the antigen structure had some influence on their immunol. property, thus verifying the potential of the oligosaccharides for vaccine development and other immunol. studies. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate
The Article related to antituberculosis vaccine oligosaccharide dimannopyranose stereoselective glycosylation were thioglycoside antibacterial, oligosaccharide preparation mycobacterial lipoarabinomannan immunol protein antibody thioglycoside glycosylation and other aspects.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate
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