On November 20, 2020, Wang, Junchang; Zhang, Yiyue; Zhu, Yirong; Liu, Junru; Chen, Yan; Cao, Xin; Yang, You published an article.Application of 79642-50-5 The title of the article was Total Synthesis and Immunological Evaluation of the Tri-D-glycero-D-manno-heptose Antigen of the Lipopolysaccharide as a Vaccine Candidate against Helicobacter pylori. And the article contained the following:
Helicobacter pylori, the most common cause of chronic gastritis, peptic ulcers and gastric cancers, infects around half of the world’s population. Although the drawbacks of the antibiotic-based combination therapy are emerging, no effective vaccine is available to prevent H. pylori infections. Here, we describe the total synthesis of the unique α-(1→3)-linked triD-glycero-D-manno-heptose antigen from the lipopolysaccharide of H. pylori sero-groups O3, O6 and strains MO19, D2, D4 and D5 based on de novo synthesis of the differentially protected D-glycero-D-manno-heptosyl building blocks. Immunization of mice with the semi-synthetic glycoconjugate elicited a very robust T-cell dependent antigen-specific immune response, resulting in very high titers of IgG1 and IgG2b protective antibody iso-types. The post-immune sera recognized H. pylori NCTC 11637 and bound strongly to the surface of the intact bacteria. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application of 79642-50-5
The Article related to human serum albumin crm197 diphteria toxin glycoconjugate, antibiotic antigen antitumor combination chemotherapy immunization glycoconjugate ig, lipopolysaccharide glyceromannoheptose antigen immunol synthesis vaccine helicobacter pylori antibacterial and other aspects.Application of 79642-50-5
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