Swiderska, Agnieszka; Coney, Andrew M.; Alzahrani, Abdulaziz A.; Aldossary, Hayyaf S.; Batis, Nikolaos; Ray, Clare J.; Kumar, Prem; Holmes, Andrew P. published an article in 2021, the title of the article was Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat.Reference of Diethyl succinate And the article contains the following content:
Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)-A specialised peripheral chemoreceptor. Central to CB O2-sensing is their unique mitochondria but the link between mitochondrial inhibition and cellular stimulation is unresolved. The objective of this study was to evaluate if ex vivo intact CB nerve activity and in vivo whole body ventilatory responses to hypoxia were modified by alterations in succinate metabolism and mitochondrial ROS (mitoROS) generation in the rat. Application of di-Et succinate (DESucc) caused concentration-dependent increases in chemoafferent frequency measuring approx. 10-30% of that induced by severe hypoxia. Inhibition of mitochondrial succinate metabolism by di-Me malonate (DMM) evoked basal excitation and attenuated the rise in chemoafferent activity in hypoxia. However, approx. 50% of the response to hypoxia was preserved. MitoTEMPO (MitoT) and 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SKQ1) (mitochondrial antioxidants) decreased chemoafferent activity in hypoxia by approx. 20-50%. In awake animals, MitoT and SKQ1 attenuated the rise in respiratory frequency during hypoxia, and SKQ1 also significantly blunted the overall hypoxic ventilatory response (HVR) by approx. 20%. Thus, while the data support a role for succinate and mitoROS in CB and whole body O2-sensing in the rat, they are not the sole mediators. Treatment of the CB with mitochondrial selective antioxidants may offer a new approach for treating CB-related cardiovascular-respiratory disorders. The experimental process involved the reaction of Diethyl succinate(cas: 123-25-1).Reference of Diethyl succinate
The Article related to succinate metabolism reactive oxygen species carotid body ventilatory hypoxia, carotid body, hypoxia, hypoxic ventilatory response, mitochondrial reactive oxygen species, succinate, succinate dehydrogenase and other aspects.Reference of Diethyl succinate
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