Holloway, Joshua O.; Mertens, Chiel; Du Prez, Filip E.; Badi, Nezha published an article in 2019, the title of the article was Automated synthesis protocol of sequence-defined oligo-urethane-amides using thiolactone chemistry.Electric Literature of 6038-19-3 And the article contains the following content:
An automated, iterative protocol for the synthesis of multifunctional, sequence-defined oligo-urethane-amides using thiolactone chem. is reported. Here, sequenced functionalization of the backbone is easily introduced using com. available primary amines. The chem. is carried out on solid phase using different supports for better optimization of the synthetic protocol and in order to demonstrate the versatility of the approach. This technique is very effective for iterative synthesis and solid-phase chem. and enables the exploration of full automation of this approach using a robotic peptide synthesizer. As a result, this automated protocol allows for the synthesis of a sequence-defined nonamer of high purity. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Electric Literature of 6038-19-3
The Article related to sequence defined oligo urethane amide synthesis peptide, amine solid phase peptide synthesis robotic synthesizer thiolactone aminolysis, aminolysis reaction kinetics, automated synthesis, sequence-controlled polymers, solid-phase, thiolactone and other aspects.Electric Literature of 6038-19-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics