On July 31, 2021, Foubert, Kenn; Dendooven, Ella; Theunis, Mart; Naessens, Tania; Ivanova, Boryana; Pieters, Luc; Gilissen, Liesbeth; Huygens, Sara; De Borggraeve, Wim; Lambert, Julien; Goossens, An; Aerts, Olivier published an article.Electric Literature of 6197-30-4 The title of the article was The presence of benzophenone in sunscreens and cosmetics containing the organic UV filter octocrylene: A laboratory study. And the article contained the following:
The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic UV filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen. Purpose: To verify if, and to what extent, BP residues are present in OCT-containing consumer products. The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chem. analyzed for the presence of BP by means of liquid chromatog. Results: In the OCT raw material and in all 28 OCT-containing products the presence of BP could be demonstrated, mostly in concentrations above 10 ppm (0.001%), whereas a majority of OCT-free products (8/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time- and temperature-dependent manner, likely due to the addnl. degradation of OCT. Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicol. and ecol. studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Electric Literature of 6197-30-4
The Article related to cosmetic environment impurity ketoprofen photocontact allergy octocrylene sunscreen toxicol, unsubstituted benzophenone, cas number 119-61-9, cosmetics, environment, impurities, ketoprofen, octocrylene, photocontact allergy, sunscreens, toxicology and other aspects.Electric Literature of 6197-30-4
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