On December 1, 2021, Falfushynska, Halina; Sokolov, Eugene P.; Fisch, Kathrin; Gazie, Hatem; Schulz-Bull, Detlef E.; Sokolova, Inna M. published an article.Application of 6197-30-4 The title of the article was Biomarker-based assessment of sublethal toxicity of organic UV filters (ensulizole and octocrylene) in a sentinel marine bivalve Mytilus edulis. And the article contained the following:
The global occurrence of organic UV filters in the marine environment is of increasing ecotoxicol. concern. Here we assessed the toxicity of UV filters ensulizole and octocrylene in the blue mussels Mytilus edulis exposed to 10 or 100μg l-1 of octocrylene and ensulizole for two weeks. An integrated battery of biochem. and mol. biomarkers related to xenobiotics metabolism and cellular toxicity (including oxidative stress, DNA damage, apoptosis, autophagy and inflammation) was used to assess the toxicity of these UV filters in the mussels. Octocrylene (but not ensulizole) accumulated in the mussel tissues during the waterborne exposures. Both studied UV filters induced sublethal toxic effects in M. edulis at the investigated concentrations These effects involved induction of oxidative stress, genotoxicity (indicated by upregulation of DNA damage sensing and repair markers), upregulation of apoptosis and inflammation, and dysregulation of the xenobiotic biotransformation system. Octocrylene induced cellular stress in a concentration-dependent manner, whereas ensulizole appeared to be more toxic at the lower (10μg l-1) studied concentration than at 100μg l-1. The different concentration-dependence of sublethal effects and distinct toxicol. profiles of ensulizole and octocrylene show that the environmental toxicity is not directly related to lipophilicity and bioaccumulation potential of these UV filters and demonstrate the importance of using bioassays for toxicity assessment of emerging pollutants in coastal marine ecosystems. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4
The Article related to mytilus biomarker ensulizole octocrylene, 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propanoate (octocrylene), apoptosis, inflammation, organic uv filters, oxidative stress, phenylbenzimidazole sulfonic acid (ensulizole) and other aspects.Application of 6197-30-4
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