Berger, Anna Lucia; Donabauer, Karsten; Koenig, Burkhard published an article in 2019, the title of the article was Photocatalytic carbanion generation from C-H bonds – reductant free Barbier/Grignard-type reactions.Formula: C7H10O3 And the article contains the following content:
A redox-neutral method for the generation of carbanions from benzylic C-H bonds in a photocatalytic Grignard-type reaction was reported. The combination of photo- and hydrogen atom transfer (HAT) catalysis enabled the abstraction of a benzylic hydrogen atom, generating a radical intermediate. This radical was reduced in situ by the organic photocatalyst to a carbanion, which was able to react with electrophiles such as aldehydes or ketones, yielding homobenzylic secondary and tertiary alcs. ArCR1R2C(OH)R3R4 [R1 = R2 = H, Me, R1 = H, R2 = Me; R3 = R4 = Me, Et, n-Bu, R3 = H, Me, R4 = Me, Et, i-Pr, etc; Ar = 2-thienyl, Ph, 4-MeOC6H4, etc.]. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Formula: C7H10O3
The Article related to organo photocatalyst preparation, tertiary alc preparation, ketone alkyl benzene barbier grignard reaction, secondary alc preparation, aldehyde alkyl benzene barbier grignard reaction and other aspects.Formula: C7H10O3
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