Yuan, Dan; Liu, Meijing; Jia, Peng; Li, Yiping; Huang, Yuling; Ye, Li; Api, Laze; Chen, Maogang; Yao, Liang; Wang, Zixin; Liu, Honglu; Liang, Shu; Yang, Shujuan published the artcile< Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is HIV virol failure genetic diversity drug resistance China; Antiretroviral therapy; Drug resistance; HIV; HIV-1 subtypes; Virological failure.
Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virol. failure on antiretroviral therapy (ART) is serious in this area. Anal. of prevalence and determinants of ART failure, the genetic diversity and drug resistance among people living with HIV (PLWH) helps improve HIV treatment efficiency and prevent HIV transmission. A total of 5157 PLWH were recruited from 2016 to 2017. The venous blood samples were subjected to RT-PCR, followed by sequencing of the HIV-1 pol gene, targeting the protease and reverse transcriptase fragments. HIV-1 diversity was analyzed using the DNAStar software and drug resistance mutations were analyzed using the Stanford University HIV Drug Resistance Database. A total of 2156 (41.81%) PLWH showed virol. failure on ART. Males (ORm = 1.25), heterosexual behaviors and drug injection (ORm = 1.44) and mother to child transmission routes (ORm = 1.58), the clin. stage of AIDS (ORm = 1.35), having used illicit drugs and shared the needles (1-4 times: ORm = 1.34; more than 5 times: ORm = 1.52), having ever replaced ART regimen (ORm = 1.48) increased the risk of virol. failure among PLWH, while higher education lever (ORm = 0.77) and ≥ 12 mo on ART (12 ∼ 36 mo: ORm = 0.72; ≥36 mo: ORm = 0.66) was associated with lower likelihood of virol. failure. The data revealed that CRF07_BC (1508, 95.62%) were the most common strains, and the drug-resistant rate was 32.10% among PLWH with virol. failure in this area. The high frequencies of drug resistance were found in EFV and NVP of NNRTIs, ABC, FTC and 3TC of NRTIs, and TPV/r in PIs. The most common mutations in NNRTIs, NRTIs and PIs were K103N/KN (64.69%), M184V/MV/I (36.29%) and Q58E/QE (4.93%), resp. We concluded that surveillance of virol. failure, HIV-1 subtypes, and drug resistance to understand HIV-1 epidemiol. and guide modification of ART guidelines, and target prevention and control strategies should be formatted to reduce the virol. failure and drug resistance to promote viral suppression and prevent HIV-1 transmission.
BMC Infectious Diseases published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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