Nguyen, Xuan B.; Nakano, Yuji; Duggan, Nisharnthi M.; Scott, Lydia; Breugst, Martin; Lupton, David W. published the artcile< N-Heterocyclic Carbene Catalyzed (5+1) Annulations Exploiting a Vinyl Dianion Synthon Strategy>, HPLC of Formula: 112-63-0, the main research area is acrylate tethered divinyl ketone NHC catalyst diastereoselective cycloisomerization annulation; hexahydroindene tetralin stereoselective preparation vinyl dianion synthon; enonyl unsaturated ester NHC catalyst dimerization cycloisomerization annulation; cyclohexanone stereoselective preparation vinyl dianion synthon; N-heterocyclic carbenes; enantioselectivity; homoenolates; organocatalysis; synthons.
Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N-heterocyclic carbene (NHC) catalyzed reactions, in which β-unsubstituted conjugate acceptors undergo homoenolate formation and C-C bond formation twice, have been developed. Specifically, the all-carbon (5+1) annulations give a range of mono- and bicyclic cyclohexanones (31 examples). In the first family of annulations, β-unsubstituted acrylates tethered to a divinyl ketone undergo cycloisomerization, providing hexahydroindenes and tetralins. In the second, partially untethered substrates undergo an intermol. (5+1) annulation involving dimerization followed by cycloisomerization. While enantioselectivity was not possible with the former, the latter proved viable, allowing cyclohexanones to be produced with high levels of enantiopurity (most >95:5 e.r.) and exclusive diastereoselectivity (>20:1 d.r.). Derivatizations and mechanistic studies are also reported.
Angewandte Chemie, International Edition published new progress about Cyclization catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics