Zhang, Jun; Wang, Xuefeng; Kuang, Yunyan; Wu, Jie published the artcile< Generation of Sulfonylated Tetrazoles through an Iron-Catalyzed Multicomponent Reaction Involving Sulfur Dioxide>, Computed Properties of 112-63-0, the main research area is cyano sulfonyl tetrazole preparation; cycloketone oxime ester alkyne trimethylsilyl azide multicomponent iron catalyst; Chemistry; Green Chemistry; Organic Chemistry; Organic Synthesis.
Herein, a five-component reaction of cycloketone oxime esters I (X = C, O; Ar = 4-trifluoromethylphenyl), alkynes, R2CCH (R2 = Ph, 1-naphthyl, cyclohex-1-en-1-yl, thiophen-3-yl, etc.) DABCO.(SO2)2, and two mols. of trimethylsilyl azide under iron catalysis is developed, giving rise to a range of cyano-containing sulfonylated tetrazoles II in moderate to good yields. This multicomponent reaction exhibits excellent selectivity and enables the formation of multiple new chem. bonds in one pot. A possible mechanism involving azidosulfonylation of alkynes, C-C bond cleavage of both cycloketone oxime esters I and alkynes, and [3 + 2] cycloaddition of trimethylsilyl azide and the nitrilium cation intermediate is proposed. Addnl., the potential of terminal alkynes acting as powerful synthons for the synthesis of tetrazoles II in a radical initiated process is demonstrated for the first time.
iScience published new progress about [3+2] Cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics