Majumdar, K. C.; Roy, B. published the artcile< Synthesis of thiochromen-4-one-annelated heterocycles: regioselective cyclization of 3-hydroxy-2-(2-cyclohexen-1-yl)thiochromen-4-one>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is regioselective cyclization cyclohexenylhydroxythiochromenone; benzofurothiochromenone preparation; thiochromenone annelated heterocycle preparation.
The title compound (I) was synthesized in 80% yield by the thermal [3,3]-sigmatropic rearrangement of 3-(2-cyclohexen-1-yloxy)thiochromen-4-one. Treatment of I with bis(benzonitrile)palladium dichloride in refluxing benzene afforded a linearly cyclized product (II) in 98% yield, which on dehydrogenation with palladized charcoal gave benzofuro[3,2-b]thiochromen-6-one. Substrate I on reaction with hexamethylenetetramine hydrotribromide gave a mixture of three products: III (35%), IV (15%), and V (20%). The same reaction when conducted with pyridine hydrotribromide furnished only the dibromide V, which was then cyclized in acetone-potassium carbonate to give IV in 85% yield. V was cyclized by heating with palladized charcoal in di-Ph ether to give a mixture of II (7%) and IV (63%). Substrate I was also cyclized in cold concentrated H2SO4 to give VI in 95% yield.
Synthetic Communications published new progress about Heterocyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics