Jarugu, Lokesh Babu; Reddy, China Anki; Chikkananjunda, Nanjundaswamy Kanikahalli; Krishnamoorthy, Suresh; Sarvanakumar, Pon; Sankar, Ulaganathan; Arunachalam, Pirama Nayagam; McDonald, Ivar M.; Olson, Richard E.; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha published the artcile< Process Optimization for the Large-Scale Preparation of (2S,3aR,7aS)-tert-Butyl Hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate, an Intermediate for Nicotinic Acetylcholine Receptor Agonists>, Formula: C19H34O2, the main research area is process optimization large scale preparation methanopyrrolopyridinecarboxylate; methanopyrrolopyridinecarboxylate preparation monoiodination Sonogashira coupling; one pot debenzylation ring hydrogenation methanopyrrolopyridinecarboxylate preparation.
An optimized large-scale synthesis of (2S,3aR,7aS)-tert-Bu hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate (I), an important intermediate for nicotinic acetylcholine receptor agonists, is described starting from the readily available and inexpensive 4-aminopyridine over in 10 steps in an overall yield of 14%. The key feature of the synthesis involves three transformations in a one-pot process, including debenzylation and ring hydrogenation of two fused bicyclic rings. Multihundred gram quantities of I were prepared
Organic Process Research & Development published new progress about Debenzylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics