Gao, Xing; Shan, Chunhui; Chen, Zhihao; Liu, Yan; Zhao, Xia; Zhang, Ao; Yu, Peng; Galons, Herve; Lan, Yu; Lu, Kui published the artcile< One-pot synthesis of β-lactams by the Ugi and Michael addition cascade reaction>, Application In Synthesis of 112-63-0, the main research area is lactam beta preparation chemoselective diastereoselective; heterocyclic aldehyde amine isocyanide maleic fumaric acid; tandem Ugi Michael addition.
Synthesis of β-lactams I (R1 = COOMe, COOEt; R2 = n-Pr, 4-MeC6H4, 4-O2NC6H4, 4-ClC6H4; R3 = COOEt, COPh, 2-pyridyl, etc.; R4 = n-Bu, t-Bu, c-hexyl, Bn) was achieved via Ugi/Michael reaction cascades under mild conditions. The intramol. hydrogen bonding between the heteroatom from an aldehyde component and the amide NH group controls the chemoselectivity of the Michael reaction vs. the aza-Michael reaction. DFT calculation was performed to clarify the mechanism, chemo-selectivity and diastereoselectivity of this work. This one-pot protocol offers a straightforward method to build a diversified β-lactam library for drug discovery.
Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics