Chime, S. A.; Attama, A. A.; Onunkwo, G. C. published the artcile< Application of SRMS 154 as Sustained Release Matrix for the Delivery of Stavudine: In vitro and in vivo Evaluation and Effect of Poloxamer 188 on the Properties of the Tablets>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is stavudine delivery micellar solidification; Area under the curve; HIV; Lipids; Solidified reverse micelles; Stavudine; Tablets..
Objectives: To formulate sustained release lipid based stavudine and to study the properties of the formulations by in vitro and in vivo methods. Methods: Stavudine tablets were formulated by molding using validated tablets molds. The carrier used were solidified reverse micellar solution (SRMS) made up of varying ratios of hydrogenated palm oil and Phospholipid admixtures Evaluation tests were carried out on the tablets using both Pharmacopoeial and non Pharmacopoeial test. Drug release was studied in both simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.2). Results: The results showed that stavudine tablets exhibited weight range of 372 ± 0.14 to 386 ± 0.52 mg, friability ranged from 0.00 to 0.13% and hardness ranged from 4.27 ± 0.25 to 5.30 ± 0.21 Kgf. Tablets formulated with SRMS 1:2 had erosion time range of 60.80 ± 1.23 to 87.90 ± 2.33 min and was affected significantly by the presence of Poloxamer 188 (p < 0.05). The formulations exhibited T100% at 10 to13 h in SIF. Stavudine tablets showed the area under the curve (AUC) of 854.0μg/h/mL, significantly higher than the AUC of the reference (p < 0.05). Conclusion: Stavudine SRMS-based tablets had good stability and sustained release properties. Formulations containing 1% Poloxamer 188 exhibited enhanced in vivo absorption and hence could be used once daily in order to enhance the bioavailability of this drug. Infectious Disorders: Drug Targets published new progress about Absorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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Ester – an overview | ScienceDirect Topics