Barton, Nick; Convery, Maire; Cooper, Anthony W. J.; Down, Kenneth; Hamblin, J. Nicole; Inglis, Graham; Peace, Simon; Rowedder, James; Rowland, Paul; Taylor, Jonathan A.; Wellaway, Natalie published the artcile< Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach>, Reference of 112-63-0, the main research area is inhibitor phosphoinositide kinase delta.
A deconstruction of previously reported phosphoinositide 3-kinase δ (PI3Kδ) inhibitors and subsequent regrowth led to the identification of a privileged fragment for PI3Kδ, which was exploited to deliver a potent, efficient, and selective lead series with a novel binding mode observed in the PI3Kδ crystal structure.
Journal of Medicinal Chemistry published new progress about Crystal structure (of phosphoinositide 3-kinase δ and inhibitor). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.
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