Yoshida, Shigeru; Unoki, Makoto published the artcile< Compounds allied to vitamin B1. I. Synthesis of 3-(2-methyl-4-amino-5-pyrimidylmethyl)-4-methyl-5-(2-hydroxyethylthio)-2-thiazolone>, Application of C19H34O2, the main research area is .
RCH2NH2.HCl (I, R = C(NH2):N.CMe:N.CH:C-) (2.1 g.) and 0.8 g. NaOH (II) in 10 ml. MeOH heated a while, filtered (to remove NaCl), mixed with 0.5 g. CS2, filtered, and washed with MeOH give 1.4 g. RCH2NHCS2NH3CH2R (III), needles, m. 235° (from hot water), less soluble in cold water, soluble in dilute acid, alkali hydroxide, and carbonate. AcCHCl(CH2)2OH (IV) prepared by boiling 0.7 g. α-aceto-α-chlorobutyrolactone (V) with 2.5 ml. 5% HCl for 1 hr., and neutralized with NaHCO3, added into 1.4 g. III in 6 ml. MeOH, heated 2-5 hrs. at 100°, filtered, washed with water, the filtrate treated with 0.21 g. Na2CO3 and 0.2 g. CS2 gives 1.2 g. VI, and the filtrate treated with IV prepared from 0.35 g. V gives 0.6 g. RCH2NHCS2-CHAc(CH2)2OH (VI), m. 255°; or treating 1.4 g. III and 0.42 g. Na2CO3 in 6 ml. water with aqueous IV (from 1.4 g. V) in 6 ml. MeOH and 0.4 g. CS2 on a water bath for several min., filtering, and washing with water give 2.4 g. VI, decompose 255°. III and AcCHCl(CH2)2OAc (VII) heated in the same way as in the preparation of VI give RCH2NHCS2-CHAc(CH2)2OAc (VIII), decompose 250°. VIII (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 heated on an oil bath 1 hr. at 140°, taken up with 5 ml. hot water, NaOH added in excess, and the product filtered and washed with water give 0.92 g. S.CS.N(CH2R).CMe:C(CH2)2OAc (IX), m. 169-70° (from dilute alc.), also prepared by refluxing the above mixture with 10 volumes dioxane. VI (1 g.) and 0.6 g. NaHSO4 or 0.2 g. AlCl3 fused on an oil bath or refluxed in dioxane give 0.8 g. S.CS.N(CH2R).CMe:C(CH2)2OH (X), m. 237-8° (from dilute alc.); hydrolysis of 1 g. IX with 0.2 g. NaOH in 13 ml. 60% alc. 10 min. on a water bath give X.
Yakugaku Zasshi published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics