Sun, Chaofeng; Peng, Fang; Li, Jianfei; Cui, Xudong; Qiao, Xin; Zhu, Wangliang published the artcile< Ferroptosis-specific inhibitor ferrostatin-1 relieves H2O2- induced redox imbalance in primary cardiomyocytes through the Nrf2/ARE pathway>, Application of C15H22N2O2, the main research area is ferrostatin 1 ferroptosis redox imbalance cardiomyocyte Nrf2 ARE pathway.
Ischemic heart disease (IHD) has always been the focus of attention of many researchers in cardiovascular disease, and its pathogenesis is also very complicated. Ferroptosis may be involved in the occurrence and development of IHD. First, primary cardiomyocytes were treated with H2O2 to simulate the IHD in vitro model. After pretreatment with different concentrations of ferrostatin-1, cell survival rate was detected by MTT method, cell apoptosis was detected by TUNEL staining and flow cytometry, and the expression of oxidative stress, ferroptosis, and related mols. of Nrf2/ARE pathway was detected by Western blotting (WB) and quant. real-time polymerase chain reaction (qRT-PCR). The mortality of primary cardiomyocytes in the H2O2 group was obviously increased. Ferrostatin-1 treatment can effectively inhibit cell death, improve antioxidant enzyme activity, inhibit the expression of ferroptosis-related mols., and activate Nrf2/ARE pathway expression. Ferroptosis-specific inhibitor ferrostatin-1 relieves H2O2-induced redox imbalance in primary cardiomyocytes through the Nrf2/ARE pathway, inhibits ferroptosis, and thereby slows cardiomyocyte death.
Disease Markers published new progress about Antioxidant enzymes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Application of C15H22N2O2.
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