Seki, Masahiko; Kondo, Kazuhiko published the artcile< A facile synthesis of (S)-4-hydroxypyrrolidin-2-one from (S)-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxypyrrolidinone preparation; pyrrolidinone hydroxy preparation.
The chiral diol (S)-HOCH2CHOHCH2CO2Me obtained from (S)-malate was subjected to regioselective tosylation to give the terminal tosylate in good yield. Subsequent treatment with aqueous NH3 afforded (S)-4-hydroxypyrrolidin-2-one through 3 steps in 32% overall yield.
Synthesis published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics