Santaniello, Enzo; Ferraboschi, Patrizia; Grisenti, Paride; Aragozzini, Fabrizio; Maconi, Elisabetta published the artcile< A biocatalytic approach to the enantioselective synthesis of (R)- and (S)-malic acid>, Application In Synthesis of 617-55-0, the main research area is malate stereoisomer; malic acid stereoisomer; oxalacetate stereoselective enzymic reduction yeast; microbial reduction stereoselective oxalacetate; resolution enzymic malate esterase; chymotrypsin enzymic resolution malate.
(S)-EtO2CCH(OH)CH2CO2Et [(S)-I] was prepared (70-80% yield; >98% optical purity) by an enantioselective reduction of EtO2CC(ONa):CHCO2Et (II) by fermenting baker’s yeast. Other microorganisms were tested, most of them afforded 8-94% enantiomeric excess (S)-I. (R)-MeO2CCH(OH)CH2CO2Me [(R)-III] was obtained from racemic III by hydrolysis with pig liver esterase, the highest enantiomeric excess (93%) being realized at 0° in 20% aqueous MeOH. Enzymic hydrolyses of protected malates did not lead to improvement of the enantiomer excess.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Enzymic reduction, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics