Qanash, Husam; Yahya, Reham; Bakri, Marwah M.; Bazaid, Abdulrahman S.; Qanash, Sultan; Shater, Abdullah F.; T. M., Abdelghany published the artcile< Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit>, Formula: C19H34O2, the main research area is anticancer antioxidant antiviral antimicrobial Dovyalis fruit.
Secondary plant metabolites remain one of the key sources of therapeutic agents despite the development of new approaches for the discovery of medicinal drugs. In the current study, chem. anal., and biol. activities of Kei apple (Dovyalis caffra) methanolic extract were evaluated. Chem. anal. was performed using HPLC and GC-MS. Antiviral and anticancer effect were assessed using the crystal violet technique and activity against human liver cells (HepG2), resp. Antibacterial activity was tested with the disk diffusion method. The obtained results showed that chlorogenic acid (2107.96 ± 0.07 μg/g), catechin (168 ± 0.58 μg/g), and gallic acid (15.66 ± 0.02 μg/g) were the main bioactive compounds identified by HPLC techniques. While, compounds containing furan moieties, as well as levoglucosenone, isochiapin B, dotriacontane, 7-nonynoic acid and tert-hexadecanethiol, with different biol. activities were identified by GC-MS. Addnl., inhibition of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging was 79.25% at 2000 μg/mL, indicating its antioxidant activity with IC50 of 728.20 ± 1.04 μg/mL. The tested extract exhibited potential anticancer activity (58.90% toxicity) against HepG2 cells at 1000 μg/mL. Potential bacterial inhibition was observed mainly against Escherichia coli and Proteus vulgaris, followed by Staphylococcus aureus and Bacillus subtilis with a diameter of growth inhibition ranging from 13 to 24 mm. While weak activities were recorded for fungi Candida albicans (10 mm). The extract showed mild antiviral activity against human coronavirus 229E with a selective index (SI) of 10.4, but not against human H3N2 (SI of 0.67). The mol. docking study′s energy ratings were in good promise with the experiment documents of antibacterial and antiviral activities. The findings suggest that D. caffra juice extract is a potential candidate for further experiments to assess its use as potential alternative therapeutic agent.
Scientific Reports published new progress about Aberia caffra. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
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