Poisson, Jean-Francois; Normant, Jean F. published the artcile< A configurationally stable alkoxy allenyl zinc reagent, en route to anti-anti vicinal amino diols>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is vicinal amino diol stereoselective preparation; alkoxy allenyl zinc configurationally stable preparation addition imine.
The reaction of an alkoxyallenyl zinc reagent with benzyl imines derived from lactic and mandelic acids proceeds highly diastereoselectively and leads to 2-amino-1,3-diol derivatives with an anti-anti pattern. Thus, successive treatment of MeOCH2OCH2CCSiMe3 with EtCMeLi and ZnBr2 in THF gave the intermediate allenyl zinc reagent I which reacted with the benzyl imines II (R = Ph, Me) in THF at -70° to give the protected anti-anti-amino alcs. III.
Organic Letters published new progress about Addition reaction, stereoselective. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics