Pfister, Helene B.; Kelly, Meagan; Qadri, Firdausi; Ryan, Edward T.; Kovac, Pavol published the artcile< Synthesis of glycocluster-containing conjugates for a vaccine against cholera>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is human Vibrio cholerae antibacterial oligosaccharide vaccine immunol thyroid BSA; click alkyne azide triazole cycloaddition catalyst preparation oligosaccharide antibacterial; glycocluster oligosaccharide dendrimer preparation vaccine against cholera antibacterial.
Glycoclusters displaying synthetic fragments of the O-specific polysaccharide (OSP) of Vibrio cholerae O1 serotype Inaba on a carbohydrate platform were prepared by Cu(I)-catalyzed azide alkyne cycloaddition (CuAAC, click chem.). The clusters were subsequently conjugated to BSA via squaric acid chem. Their immunoreactivity was compared with those of similar conventional conjugates, i.e. made from single oligosaccharides presented in non cluster form, using plasma of patients recovering from cholera. The results showed that the conjugates were displayed in immunol. relevant manners and that the immunoreactivity of hexasaccharide-cluster conjugates was similar to that of a conjugate displaying OSP isolated from wild type V. cholerae, further supporting the immunol. relevance of antigens made from synthetic oligosaccharides.
Organic & Biomolecular Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics