Patra, Atanu; Gelat, Fabien; Pannecoucke, Xavier; Poisson, Thomas; Besset, Tatiana; Biju, Akkattu T. published the artcile< Synthesis of 4-Difluoromethylquinolines by NHC-Catalyzed Umpolung of Imines>, Computed Properties of 112-63-0, the main research area is aldimine preparation heterocyclic carbene catalyzed umpolung intramol cyclization; fluoromethylquinoline preparation; benzaldehyde condensation fluoropropenylaniline.
The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines for the synthesis of 4-difluoromethylquinoline derivatives is reported. In the presence of NHCs, the intramol. cyclization of aldimines bearing a moderately electron-poor double bond due to the presence of the -CF3 group likely proceeds via the intermediacy of the aza-Breslow intermediate. The key to the success of this aza-Stetter type transformation is the NHC generated from the bicyclic triazolium salt using DBU as the base.
Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics