Pang, Xianwu; Tang, Kailing; He, Qin; Huang, Jinghua; Fang, Ningye; Zhou, Xinjuan; Zhu, Qiuying; Wu, Xiuling; Shen, Zhiyong; Liang, Shujia published the artcile< HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China>, Synthetic Route of 112-63-0, the main research area is HIV drug resistance and HIV1 transmission diagnosis Southwest China; Antiretroviral resistance; Antiretroviral therapy; HIV drug resistance; Human immunodeficiency virus 1; Primary antiretroviral resistance; Transmitted drug resistance.
The widespread use of antiretroviral therapy (ART) has resulted in the development of transmitted drug resistance (TDR), which reduces ART efficacy. We explored TDR prevalence and its associated risk factors in newly diagnosed individuals in Guangxi. We enrolled 1324 participants who were newly diagnosed with HIV-1 and had not received ART at voluntary counselling and testing centers (VCT) in Guangxi, China, who had not received ART. Phylogenetic relationship, transmission cluster, and genotypic drug resistance analyses were performed using HIV-1 pol sequences. We analyzed the association of demog. and virol. factors with TDR. In total, 1151 sequences were sequenced successfully, of which 83 (7.21%) showed evidence of TDR. Multivariate logistic regression anal. revealed that there was significant difference between the prevalence of TDR and unmarried status (adjusted odds ratio (aOR) = 2.41, 95% CI: 1.23-4.71), and CRF08_BC subtype (aOR = 2.03, 95% CI: 1.13-3.64). Most cases of TDR were related to resistance to non-nucleoside reverse transcriptase inhibitors (4.87%) and V179E was the most common mutation detected. We identified a total of 119 HIV transmission clusters (n = 585, 50.8%), of which 18 (15.1%) clusters showed evidence of TDR (36, 41.86%). Three clusters were identified that included drug-resistant individuals having a transmission relationship with each other. The following parameters were associated with TDR transmission risk: Unmarried status, educational level of junior high school or below, and CRF08_BC subtype may be a risk of the transmission of TDR. Our findings indicated that moderate TDR prevalence and highlighted the importance of continuous TDR monitoring and designing of strategies for TDR mitigation.
BMC Infectious Diseases published new progress about Antiviral agent resistance. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
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