Onodera, Kou; Takashima, Ryo; Suzuki, Yumiko published the artcile< Selective Synthesis of Acylated Cross-Benzoins from Acylals and Aldehydes via N-Heterocyclic Carbene Catalysis>, Application of C19H34O2, the main research area is acetoxyketone preparation chemoselective; acylal aldehyde cross benzoin reaction nitrogen heterocyclic carbene catalyst.
The utility of acylals as building blocks for selective cross-benzoin synthesis was explored in this study. The synthesis of α-acetoxyketones (O-acyl cross-benzoins) I (R1 = Ph, 2-FC6H4, 2-ClC6H4, etc.; R2 = Me; R3 = Ph, 2-furyl, CH2CH2Ph, etc.) was achieved via selective N-heterocyclic carbene-catalyzed cross-benzoin reactions using acylals as aldehyde equivalent Thus, the combination of ortho-substituted Ph acylals and aromatic/aliphatic aldehydes as coupling substrates using bicyclic triazolium salts as precatalysts and potassium carbonate as a base in THF at reflux temperature selectively yielded O-acyl cross-benzoins.
Organic Letters published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics